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I just did an experiment using DMR++ files stored in a requestor pays bucket.
At a high level it took 40sec to lazily open one subgroup in one of the hdf5 files using virtualizarr and it took ~3sec to open the full dataset described by one of the dmr++ files (I know that's not apples to apples, but ¯\(ツ)/¯ ). I wanted to drop a link over here in case it serves as a useful jumping off point for someone else: https://gist.github.com/jsignell/9e5683cd114fb34d4a0b92fc85ffc951
Running the notebook requires you to have AWS creds as env vars. If you have access it does run on https://hub.openveda.cloud
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