diff --git a/scripts/release/rpm/azure-cli.spec b/scripts/release/rpm/azure-cli.spec
index fa4a2bc8329..e183409a677 100644
--- a/scripts/release/rpm/azure-cli.spec
+++ b/scripts/release/rpm/azure-cli.spec
@@ -51,14 +51,23 @@ deactivate
 # Fix up %{buildroot} appearing in some files...
 for d in %{buildroot}%{cli_lib_dir}/bin/*; do perl -p -i -e "s#%{buildroot}##g" $d; done;
 
-# Create executable
+# Create executable (entry script)
+
+# For PYTHONPATH:
+#   - We can't use %{_libdir} (expands to absolute path '/usr/lib64'), because we need to support customized
+#     installation location: https://github.com/Azure/azure-cli/pull/17491
+#   - We also can't use %{_lib}, because %{_lib} expands to different values on difference OSes：
+#     https://github.com/Azure/azure-cli/pull/20061
+#     - Fedora/CentOS/RedHat: relative path 'lib64'
+#     - Mariner: abolute path '/usr/lib'
+# The only solution left is to hard-code 'lib64' as we only release 64-bit RPM packages.
 mkdir -p %{buildroot}%{_bindir}
 python_version=$(ls %{buildroot}%{cli_lib_dir}/lib/ | head -n 1)
 printf "#!/usr/bin/env bash
 bin_dir=\`cd \"\$(dirname \"\$BASH_SOURCE[0]\")\"; pwd\`
 python_cmd=%{python_cmd}
 if command -v ${python_version} &>/dev/null; then python_cmd=${python_version}; fi
-AZ_INSTALLER=RPM PYTHONPATH=\"\$bin_dir\"/../%{_lib}/az/lib/${python_version}/site-packages \$python_cmd -sm azure.cli \"\$@\"
+AZ_INSTALLER=RPM PYTHONPATH=\"\$bin_dir/../lib64/az/lib/${python_version}/site-packages\" \$python_cmd -sm azure.cli \"\$@\"
 " > %{buildroot}%{_bindir}/az
 rm %{buildroot}%{cli_lib_dir}/bin/python* %{buildroot}%{cli_lib_dir}/bin/pip*