diff --git a/src/wp-includes/global-styles-and-settings.php b/src/wp-includes/global-styles-and-settings.php
index efc2edcaaa354..49fccc7a3e37a 100644
--- a/src/wp-includes/global-styles-and-settings.php
+++ b/src/wp-includes/global-styles-and-settings.php
@@ -93,7 +93,15 @@ function wp_get_global_stylesheet( $types = array() ) {
 		( ! defined( 'WP_DEBUG' ) || ! WP_DEBUG ) &&
 		( ! defined( 'SCRIPT_DEBUG' ) || ! SCRIPT_DEBUG ) &&
 		( ! defined( 'REST_REQUEST' ) || ! REST_REQUEST ) &&
-		! is_admin()
+		! is_admin() &&
+		/**
+		 * Whether to enable the global styles stylesheet cache.
+		 *
+		 * @since 6.0.0
+		 *
+		 * @param bool $enable True to enable transient cache, false otherwise.
+		 */
+		apply_filters( 'global_styles_enable_cache', true )
 	);
 	$transient_name = 'global_styles_' . get_stylesheet();
 	if ( $can_use_cached ) {
@@ -165,7 +173,9 @@ function wp_get_global_styles_svg_filters() {
 		( ! defined( 'WP_DEBUG' ) || ! WP_DEBUG ) &&
 		( ! defined( 'SCRIPT_DEBUG' ) || ! SCRIPT_DEBUG ) &&
 		( ! defined( 'REST_REQUEST' ) || ! REST_REQUEST ) &&
-		! is_admin()
+		! is_admin() &&
+		/** This filter is documented in wp-includes/global-styles-and-settings.php */
+		apply_filters( 'global_styles_enable_cache', true )
 	);
 	$transient_name = 'global_styles_svg_filters_' . get_stylesheet();
 	if ( $can_use_cached ) {