diff --git a/metadata-ingestion/README.md b/metadata-ingestion/README.md
index 79f0a9f4af587a..a7561249fe94cb 100644
--- a/metadata-ingestion/README.md
+++ b/metadata-ingestion/README.md
@@ -190,6 +190,8 @@ source:
 
 ### Microsoft SQL Server Metadata `mssql`
 
+We have two options for the underlying library used to connect to SQL Server: (1) [python-tds](https://github.com/denisenkom/pytds) and (2) [pyodbc](https://github.com/mkleehammer/pyodbc). The TDS library is pure Python and hence easier to install, but only PyODBC supports encrypted connections.
+
 Extracts:
 
 - List of databases, schema, and tables
@@ -216,8 +218,40 @@ source:
       # documentation will be a good reference for what is supported. To find which dialect is likely
       # in use, consult this table: https://docs.sqlalchemy.org/en/14/dialects/index.html.
       charset: "utf8"
+    # If set to true, we'll use the pyodbc library. This requires you to have
+    # already installed the Microsoft ODBC Driver for SQL Server.
+    # See https://docs.microsoft.com/en-us/sql/connect/python/pyodbc/step-1-configure-development-environment-for-pyodbc-python-development?view=sql-server-ver15
+    use_odbc: False
+    uri_args: {}
+```
+
+<details>
+  <summary>Example: using ingestion with ODBC and encryption</summary>
+
+This requires you to have already installed the Microsoft ODBC Driver for SQL Server.
+See https://docs.microsoft.com/en-us/sql/connect/python/pyodbc/step-1-configure-development-environment-for-pyodbc-python-development?view=sql-server-ver15
+
+```yml
+source:
+  type: mssql
+  config:
+    # See https://docs.sqlalchemy.org/en/14/dialects/mssql.html#module-sqlalchemy.dialects.mssql.pyodbc
+    use_odbc: True
+    username: user
+    password: pass
+    host_port: localhost:1433
+    database: DemoDatabase
+    uri_args:
+      # See https://docs.microsoft.com/en-us/sql/connect/odbc/dsn-connection-string-attribute?view=sql-server-ver15
+      driver: "ODBC Driver 17 for SQL Server"
+      Encrypt: "yes"
+      TrustServerCertificate: "Yes"
+      ssl: "True"
+      # Trusted_Connection: "yes"
 ```
 
+</details>
+
 ### Hive `hive`
 
 Extracts:
diff --git a/metadata-ingestion/setup.py b/metadata-ingestion/setup.py
index 53bfc8507f8a3e..df6813de8cc5e7 100644
--- a/metadata-ingestion/setup.py
+++ b/metadata-ingestion/setup.py
@@ -77,6 +77,7 @@ def get_long_description():
         "acryl-pyhive[hive]>=0.6.6"
     },
     "mssql": sql_common | {"sqlalchemy-pytds>=0.3"},
+    "mssql-odbc": sql_common | {"pyodbc"},
     "mysql": sql_common | {"pymysql>=1.0.2"},
     "postgres": sql_common | {"psycopg2-binary", "GeoAlchemy2"},
     "redshift": sql_common | {"sqlalchemy-redshift", "psycopg2-binary", "GeoAlchemy2"},
diff --git a/metadata-ingestion/src/datahub/ingestion/source/mssql.py b/metadata-ingestion/src/datahub/ingestion/source/mssql.py
index d257806fa2b812..8f7cb8a8edffe4 100644
--- a/metadata-ingestion/src/datahub/ingestion/source/mssql.py
+++ b/metadata-ingestion/src/datahub/ingestion/source/mssql.py
@@ -1,3 +1,8 @@
+import urllib.parse
+from typing import Dict
+
+import pydantic
+
 # This import verifies that the dependencies are available.
 import sqlalchemy_pytds  # noqa: F401
 
@@ -9,6 +14,29 @@ class SQLServerConfig(BasicSQLAlchemyConfig):
     host_port = "localhost:1433"
     scheme = "mssql+pytds"
 
+    use_odbc: bool = False
+    uri_args: Dict[str, str] = {}
+
+    @pydantic.validator("uri_args")
+    def passwords_match(cls, v, values, **kwargs):
+        if values["use_odbc"] and "driver" not in v:
+            raise ValueError("uri_args must contain a 'driver' option")
+        elif not values["use_odbc"] and v:
+            raise ValueError("uri_args is not supported when ODBC is disabled")
+        return v
+
+    def get_sql_alchemy_url(self):
+        if self.use_odbc:
+            # Ensure that the import is available.
+            import pyodbc  # noqa: F401
+
+            self.scheme = "mssql+pyodbc"
+        uri = super().get_sql_alchemy_url()
+
+        if self.use_odbc:
+            uri = f"{uri}?{urllib.parse.urlencode(self.uri_args)}"
+        return uri
+
     def get_identifier(self, schema: str, table: str) -> str:
         regular = f"{schema}.{table}"
         if self.database:
diff --git a/metadata-ingestion/tests/integration/sql_server/mssql_to_file.yml b/metadata-ingestion/tests/integration/sql_server/mssql_to_file.yml
index 78a3f8f782b354..c53e3cf6b80452 100644
--- a/metadata-ingestion/tests/integration/sql_server/mssql_to_file.yml
+++ b/metadata-ingestion/tests/integration/sql_server/mssql_to_file.yml
@@ -7,8 +7,11 @@ source:
     password: test!Password
     database: DemoData
     host_port: localhost:51433
+    # use_odbc: True
+    # uri_args:
+    #   driver: "ODBC Driver 17 for SQL Server"
 
 sink:
   type: file
   config:
-    filename: './mssql_mces.json'
+    filename: "./mssql_mces.json"