- PPIXpress and PPICompare are two webservers that enable analysis of protein-protein interaction networks (PPINs).
- Given a reference PPIN and user-uploaded expression data from multiple samples, PPIXpress constructs context-dependent PPINs based on major transcripts and high-confidence domain interactions data.
- To derive a differential PPIN that distinguishes two groups of contextualized PPINs, PPICompare identifies statistically significant altered interactions between multiple context-dependent PPINs from PPIXpress.
PPIXpress and PPICompare webservers are available at https://service.bioinformatik.uni-saarland.de/ppi-webserver/index_PPIXpress.jsp and https://service.bioinformatik.uni-saarland.de/ppi-webserver/index_PPICompare.jsp
Application updates can be found at https://service.bioinformatik.uni-saarland.de/ppi-webserver/