diff --git a/src/coreclr/jit/compiler.h b/src/coreclr/jit/compiler.h
index fbafd6e9a844d9..d27b5e9736246c 100644
--- a/src/coreclr/jit/compiler.h
+++ b/src/coreclr/jit/compiler.h
@@ -9218,10 +9218,14 @@ XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
 #endif
 
         // true if we should use the PINVOKE_{BEGIN,END} helpers instead of generating
-        // PInvoke transitions inline.
+        // PInvoke transitions inline. Normally used by R2R, but also used when generating a reverse pinvoke frame, as
+        // the current logic for frame setup initializes and pushes
+        // the InlinedCallFrame before performing the Reverse PInvoke transition, which is invalid (as frames cannot
+        // safely be pushed/popped while the thread is in a preemptive state.).
         bool ShouldUsePInvokeHelpers()
         {
-            return jitFlags->IsSet(JitFlags::JIT_FLAG_USE_PINVOKE_HELPERS);
+            return jitFlags->IsSet(JitFlags::JIT_FLAG_USE_PINVOKE_HELPERS) ||
+                   jitFlags->IsSet(JitFlags::JIT_FLAG_REVERSE_PINVOKE);
         }
 
         // true if we should use insert the REVERSE_PINVOKE_{ENTER,EXIT} helpers in the method