diff --git a/eng/pipelines/common/platform-matrix.yml b/eng/pipelines/common/platform-matrix.yml
index 3672691bbb05a3..efa204878083a7 100644
--- a/eng/pipelines/common/platform-matrix.yml
+++ b/eng/pipelines/common/platform-matrix.yml
@@ -209,6 +209,32 @@ jobs:
         ${{ insert }}: ${{ parameters.jobParameters }}
         buildingOnSourceBuildImage: true
 
+# Linux s390x
+
+- ${{ if or(containsValue(parameters.platforms, 'Linux_s390x'), in(parameters.platformGroup, 'all', 'gcstress')) }}:
+  - template: xplat-setup.yml
+    parameters:
+      jobTemplate: ${{ parameters.jobTemplate }}
+      helixQueuesTemplate: ${{ parameters.helixQueuesTemplate }}
+      variables: ${{ parameters.variables }}
+      osGroup: Linux
+      archType: s390x
+      targetRid: linux-s390x
+      platform: Linux_s390x
+      container:
+        image: ubuntu-18.04-cross-s390x-20201102145728-d6e0352
+        registry: mcr
+      jobParameters:
+        runtimeFlavor: ${{ parameters.runtimeFlavor }}
+        stagedBuild: ${{ parameters.stagedBuild }}
+        buildConfig: ${{ parameters.buildConfig }}
+        ${{ if eq(parameters.passPlatforms, true) }}:
+          platforms: ${{ parameters.platforms }}
+        helixQueueGroup: ${{ parameters.helixQueueGroup }}
+        crossBuild: true
+        crossrootfsDir: '/crossrootfs/s390x'
+        ${{ insert }}: ${{ parameters.jobParameters }}
+
 # WebAssembly
 
 - ${{ if containsValue(parameters.platforms, 'Browser_wasm') }}:
diff --git a/eng/pipelines/libraries/helix-queues-setup.yml b/eng/pipelines/libraries/helix-queues-setup.yml
index 5a82951839ff4a..73432c9c408b1a 100644
--- a/eng/pipelines/libraries/helix-queues-setup.yml
+++ b/eng/pipelines/libraries/helix-queues-setup.yml
@@ -82,6 +82,10 @@ jobs:
         # Limiting interp runs as we don't need as much coverage.
         - (Debian.10.Amd64.Open)Ubuntu.1804.Amd64.Open@mcr.microsoft.com/dotnet-buildtools/prereqs:debian-10-helix-amd64-20210304164434-56c6673
 
+    # Linux s390x
+    - ${{ if eq(parameters.platform, 'Linux_s390x') }}:
+        - Ubuntu.2004.S390X.Experimental.Open
+
     # OSX arm64
     - ${{ if eq(parameters.platform, 'OSX_arm64') }}:
       - OSX.1100.ARM64.Open
diff --git a/eng/pipelines/runtime-community.yml b/eng/pipelines/runtime-community.yml
new file mode 100644
index 00000000000000..5bebcc00a2663e
--- /dev/null
+++ b/eng/pipelines/runtime-community.yml
@@ -0,0 +1,59 @@
+trigger: none
+
+schedules:
+  - cron: "0 7,19 * * *" # run at 7:00 and 19:00 (UTC) which is 23:00 and 11:00 (PST).
+    displayName: Runtime-community default schedule
+    branches:
+      include:
+      - main
+    always: false # run only if there were changes since the last successful scheduled run.
+
+variables:
+  - template: /eng/pipelines/common/variables.yml
+
+jobs:
+#
+# Evaluate paths
+#
+- ${{ if eq(variables.dependOnEvaluatePaths, true) }}:
+  - template: /eng/pipelines/common/evaluate-default-paths.yml
+
+#
+# s390x
+# Build the whole product using Mono and run libraries tests
+#
+- template: /eng/pipelines/common/platform-matrix.yml
+  parameters:
+    jobTemplate: /eng/pipelines/common/global-build-job.yml
+    helixQueuesTemplate: /eng/pipelines/libraries/helix-queues-setup.yml
+    buildConfig: Release
+    runtimeFlavor: mono
+    platforms:
+    - Linux_s390x
+    variables:
+      # map dependencies variables to local variables
+      - name: librariesContainsChange
+        value: $[ dependencies.evaluate_paths.outputs['SetPathVars_libraries.containsChange'] ]
+      - name: monoContainsChange
+        value: $[ dependencies.evaluate_paths.outputs['SetPathVars_mono.containsChange'] ]
+    jobParameters:
+      testGroup: innerloop
+      nameSuffix: AllSubsets_Mono
+      buildArgs: -s mono+libs+host+packs+libs.tests -c $(_BuildConfig) /p:ArchiveTests=true
+      timeoutInMinutes: 180
+      condition: >-
+        or(
+          eq(dependencies.evaluate_paths.outputs['SetPathVars_libraries.containsChange'], true),
+          eq(dependencies.evaluate_paths.outputs['SetPathVars_mono.containsChange'], true),
+          eq(dependencies.evaluate_paths.outputs['SetPathVars_installer.containsChange'], true),
+          eq(variables['isFullMatrix'], true))
+      # extra steps, run tests
+      extraStepsTemplate: /eng/pipelines/libraries/helix.yml
+      extraStepsParameters:
+        creator: dotnet-bot
+        testRunNamePrefixSuffix: Mono_$(_BuildConfig)
+        condition: >-
+          or(
+          eq(variables['librariesContainsChange'], true),
+          eq(variables['monoContainsChange'], true),
+          eq(variables['isFullMatrix'], true))
diff --git a/src/libraries/tests.proj b/src/libraries/tests.proj
index b3a8575c047362..2e1ffe3b100e9d 100644
--- a/src/libraries/tests.proj
+++ b/src/libraries/tests.proj
@@ -258,6 +258,10 @@
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Security.Cryptography.OpenSsl/tests/System.Security.Cryptography.OpenSsl.Tests.csproj" />
   </ItemGroup>
 
+  <ItemGroup Condition="'$(TargetArchitecture)' == 's390x' and '$(RunDisableds390xTests)' != 'true'">
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Drawing.Common\tests\System.Drawing.Common.Tests.csproj" />
+  </ItemGroup>
+
   <ItemGroup Condition="'$(TestSingleFile)' == 'true'">
     <!-- Run only a small randomly chosen set of passing test suites -->
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)*\tests\**\*.Tests.csproj" />