diff --git a/src/tests/issues.targets b/src/tests/issues.targets
index 90b09a6fdf7c55..47b8f3981b8459 100644
--- a/src/tests/issues.targets
+++ b/src/tests/issues.targets
@@ -195,6 +195,10 @@
         <ExcludeList Include="$(XunitTestBinBase)/JIT/jit64/regress/vsw/373472/**">
             <Issue>Allocates large contiguous array that is not consistently available on 32-bit platforms</Issue>
         </ExcludeList>
+        <!-- Arm32 does not support hardware intrinsics -->
+        <ExcludeList Include = "$(XunitTestBinBase)/JIT/HardwareIntrinsics/**">
+            <Issue>https://github.com/dotnet/runtime/issues/60154</Issue>
+        </ExcludeList>
     </ItemGroup>
 
     <!-- Arm64 All OS -->
@@ -235,6 +239,17 @@
         <ExcludeList Include="$(XunitTestBinBase)/Interop/PInvoke/Generics/GenericsTest/*">
             <Issue>https://github.com/dotnet/runtime/issues/60036</Issue>
         </ExcludeList>
+        <!-- Arm64 does not support Vector256 -->
+        <ExcludeList Include = "$(XunitTestBinBase)/JIT/HardwareIntrinsics/General/Vector256/**">
+            <Issue>https://github.com/dotnet/runtime/issues/60154</Issue>
+        </ExcludeList>
+        <ExcludeList Include = "$(XunitTestBinBase)/JIT/HardwareIntrinsics/General/Vector256_1/**">
+            <Issue>https://github.com/dotnet/runtime/issues/60154</Issue>
+        </ExcludeList>
+        <!-- Arm64 does not support X86 hardware intrinsics -->
+        <ExcludeList Include = "$(XunitTestBinBase)/JIT/HardwareIntrinsics/X86/**">
+            <Issue>https://github.com/dotnet/runtime/issues/60154</Issue>
+        </ExcludeList>
     </ItemGroup>
 
     <!-- Windows all architecture excludes -->
@@ -252,6 +267,17 @@
         <ExcludeList Include="$(XunitTestBinBase)/Regressions/coreclr/GitHub_34094/Test34094/*">
             <Issue>https://github.com/dotnet/runtime/issues/57458</Issue>
         </ExcludeList>
+        <!-- X64 does not support Vector64 -->
+        <ExcludeList Include = "$(XunitTestBinBase)/JIT/HardwareIntrinsics/General/Vector64/**">
+            <Issue>https://github.com/dotnet/runtime/issues/60154</Issue>
+        </ExcludeList>
+        <ExcludeList Include = "$(XunitTestBinBase)/JIT/HardwareIntrinsics/General/Vector64_1/**">
+            <Issue>https://github.com/dotnet/runtime/issues/60154</Issue>
+        </ExcludeList>
+        <!-- X64 does not support Arm hardware intrinsics -->
+        <ExcludeList Include = "$(XunitTestBinBase)/JIT/HardwareIntrinsics/Arm/**">
+            <Issue>https://github.com/dotnet/runtime/issues/60154</Issue>
+        </ExcludeList>
     </ItemGroup>
 
     <!-- Windows x86 specific excludes -->
@@ -286,6 +312,17 @@
         <ExcludeList Include="$(XunitTestBinBase)/Regressions/coreclr/GitHub_34094/Test34094/*">
             <Issue>https://github.com/dotnet/runtime/issues/57458</Issue>
         </ExcludeList>
+        <!-- X86 does not support Vector64 -->
+        <ExcludeList Include = "$(XunitTestBinBase)/JIT/HardwareIntrinsics/General/Vector64/**">
+            <Issue>https://github.com/dotnet/runtime/issues/60154</Issue>
+        </ExcludeList>
+        <ExcludeList Include = "$(XunitTestBinBase)/JIT/HardwareIntrinsics/General/Vector64_1/**">
+            <Issue>https://github.com/dotnet/runtime/issues/60154</Issue>
+        </ExcludeList>
+        <!-- X86 does not support Arm hardware intrinsics -->
+        <ExcludeList Include = "$(XunitTestBinBase)/JIT/HardwareIntrinsics/Arm/**">
+            <Issue>https://github.com/dotnet/runtime/issues/60154</Issue>
+        </ExcludeList>
     </ItemGroup>
 
     <!-- Windows arm32 specific excludes -->
@@ -568,6 +605,17 @@
         <ExcludeList Include="$(XunitTestBinBase)/JIT/Regression/JitBlue/GitHub_19601/Github_19601/*">
             <Issue>Needs Triage</Issue>
         </ExcludeList>
+        <!-- X64 does not support Vector64 -->
+        <ExcludeList Include = "$(XunitTestBinBase)/JIT/HardwareIntrinsics/General/Vector64/**">
+            <Issue>https://github.com/dotnet/runtime/issues/60154</Issue>
+        </ExcludeList>
+        <ExcludeList Include = "$(XunitTestBinBase)/JIT/HardwareIntrinsics/General/Vector64_1/**">
+            <Issue>https://github.com/dotnet/runtime/issues/60154</Issue>
+        </ExcludeList>
+        <!-- X64 does not support Arm hardware intrinsics -->
+        <ExcludeList Include = "$(XunitTestBinBase)/JIT/HardwareIntrinsics/Arm/**">
+            <Issue>https://github.com/dotnet/runtime/issues/60154</Issue>
+        </ExcludeList>
     </ItemGroup>
 
     <!-- Unix arm64 specific -->
@@ -590,9 +638,6 @@
         <ExcludeList Include="$(XunitTestBinBase)/GC/Scenarios/DoublinkList/dlstack/*">
             <Issue>Release only crash</Issue>
         </ExcludeList>
-        <ExcludeList Include="$(XunitTestBinBase)/JIT/HardwareIntrinsics/General/Vector256/**">
-            <Issue>https://github.com/dotnet/runtime/issues/60154</Issue>
-        </ExcludeList>
     </ItemGroup>
 
     <!-- Unix arm32 specific -->
@@ -606,9 +651,6 @@
         <ExcludeList Include="$(XunitTestBinBase)/profiler/multiple/multiple/*">
             <Issue>https://github.com/dotnet/runtime/issues/57875</Issue>
         </ExcludeList>
-        <ExcludeList Include="$(XunitTestBinBase)/JIT/HardwareIntrinsics/General/Vector256/**">
-            <Issue>https://github.com/dotnet/runtime/issues/60154</Issue>
-        </ExcludeList>
     </ItemGroup>
 
     <!-- Tests that need to be triaged for vararg usage as that is not supported -->