diff --git a/src/coreclr/jit/lsra.cpp b/src/coreclr/jit/lsra.cpp
index 144d5f3ab17753..4417858838d548 100644
--- a/src/coreclr/jit/lsra.cpp
+++ b/src/coreclr/jit/lsra.cpp
@@ -2721,7 +2721,11 @@ bool LinearScan::isMatchingConstant(RegRecord* physRegRecord, RefPosition* refPo
 
         case GT_CNS_VEC:
         {
-            return GenTreeVecCon::Equals(refPosition->treeNode->AsVecCon(), otherTreeNode->AsVecCon());
+            return
+#if FEATURE_PARTIAL_SIMD_CALLEE_SAVE
+                !Compiler::varTypeNeedsPartialCalleeSave(physRegRecord->assignedInterval->registerType) &&
+#endif
+                GenTreeVecCon::Equals(refPosition->treeNode->AsVecCon(), otherTreeNode->AsVecCon());
         }
 
         default: