diff --git a/src/coreclr/jit/redundantbranchopts.cpp b/src/coreclr/jit/redundantbranchopts.cpp
index 55443f60a15464..9fa10a7b83a139 100644
--- a/src/coreclr/jit/redundantbranchopts.cpp
+++ b/src/coreclr/jit/redundantbranchopts.cpp
@@ -1961,9 +1961,8 @@ bool Compiler::optRedundantRelop(BasicBlock* const block)
             continue;
         }
 
-        // If the lcl defined here is live out, forward sub is problematic.
-        // We'll either create a redundant tree (as the original won't be dead)
-        // or lose the def (if we actually move the RHS tree).
+        // If the lcl defined here is live out we'll create a redundant tree
+        // (as the original won't be dead).
         //
         if (VarSetOps::IsMember(this, block->bbLiveOut, prevTreeLclDsc->lvVarIndex))
         {
@@ -1971,6 +1970,17 @@ bool Compiler::optRedundantRelop(BasicBlock* const block)
             continue;
         }
 
+        // The local may have uses between the def and the JTRUE. Duplicating
+        // reads is not allowed and in any case duplicating it in this case is
+        // probably not be worth it from a profitability perspective.
+        //
+        LclSsaVarDsc* ssaDefDsc = prevTreeLclDsc->GetPerSsaData(prevTreeLHS->AsLclVarCommon()->GetSsaNum());
+        if (ssaDefDsc->GetNumUses() >= 2)
+        {
+            JITDUMP(" -- prev tree lcl V%02u has up to %d uses\n", prevTreeLcl, ssaDefDsc->GetNumUses());
+            continue;
+        }
+
         JITDUMP(" -- prev tree is viable candidate for relop fwd sub!\n");
         candidateTree       = prevTreeRHS;
         candidateStmt       = prevStmt;