diff --git a/eng/pipelines/runtime.yml b/eng/pipelines/runtime.yml
index 167838aab80c33..27a5f568c5e0f7 100644
--- a/eng/pipelines/runtime.yml
+++ b/eng/pipelines/runtime.yml
@@ -415,17 +415,23 @@ extends:
           platforms:
             - browser_wasm
           alwaysRun: ${{ variables.isRollingBuild }}
+          extraBuildArgs: /p:RunSmokeTestsOnlyForNodeJs=true
+          extraHelixArgs: /p:RunSmokeTestsOnlyForNodeJs=true
           scenarios:
             - normal
             - WasmTestOnBrowser
+            - WasmTestOnNodeJs
 
       - template: /eng/pipelines/common/templates/wasm-library-tests.yml
         parameters:
           platforms:
             - browser_wasm_win
           alwaysRun: ${{ variables.isRollingBuild }}
+          extraBuildArgs: /p:RunSmokeTestsOnlyForNodeJs=true
+          extraHelixArgs: /p:RunSmokeTestsOnlyForNodeJs=true
           scenarios:
             - WasmTestOnBrowser
+            - WasmTestOnNodeJs
 
       # EAT Library tests - only run on linux
       - template: /eng/pipelines/common/templates/wasm-library-aot-tests.yml
diff --git a/src/libraries/sendtohelix-wasm.targets b/src/libraries/sendtohelix-wasm.targets
index 30654620bc14b6..425cdf37d9669b 100644
--- a/src/libraries/sendtohelix-wasm.targets
+++ b/src/libraries/sendtohelix-wasm.targets
@@ -204,8 +204,12 @@
     <ItemGroup Label="Add samples">
       <_WasmWorkItem Include="$(TestArchiveRoot)browseronly/**/*.zip"     Condition="'$(Scenario)' == 'WasmTestOnBrowser'" />
       <_WasmWorkItem Include="$(TestArchiveRoot)browserornodejs/**/*.zip" Condition="'$(Scenario)' == 'WasmTestOnBrowser'" />
-      <_WasmWorkItem Include="$(TestArchiveRoot)browserornodejs/**/*.zip" Condition="'$(Scenario)' == 'WasmTestOnNodeJS'" />
-      <_WasmWorkItem Include="$(TestArchiveRoot)nodejsonly/**/*.zip"      Condition="'$(Scenario)' == 'WasmTestOnNodeJS'" />
+      <_WasmWorkItem Include="$(TestArchiveRoot)browserornodejs/**/*.zip" Condition="'$(Scenario)' == 'WasmTestOnNodeJS' and '$(RunSmokeTestsOnlyForNodeJs)' != 'true'" />
+      <_WasmWorkItem Include="$(TestArchiveRoot)nodejsonly/**/*.zip"      Condition="'$(Scenario)' == 'WasmTestOnNodeJS' and '$(RunSmokeTestsOnlyForNodeJs)' != 'true'" />
+      
+      <HelixWorkItem Remove="*" Condition="'$(Scenario)' == 'WasmTestOnNodeJS' and '$(RunSmokeTestsOnlyForNodeJs)' == 'true'" />
+      <_WasmWorkItem Include="$(TestArchiveRoot)**/System.Net.Http.Functional.Tests.zip" Condition="'$(Scenario)' == 'WasmTestOnNodeJS' and '$(RunSmokeTestsOnlyForNodeJs)' == 'true'" />
+      <_WasmWorkItem Include="$(TestArchiveRoot)**/System.Net.WebSockets.Client.Tests.zip" Condition="'$(Scenario)' == 'WasmTestOnNodeJS' and '$(RunSmokeTestsOnlyForNodeJs)' == 'true'" />
 
       <HelixWorkItem Include="@(_WasmWorkItem -> '$(WorkItemPrefix)%(FileName)')">
         <PayloadArchive>%(Identity)</PayloadArchive>
diff --git a/src/libraries/tests.proj b/src/libraries/tests.proj
index b9896f104b24cc..c75333b9ac27f2 100644
--- a/src/libraries/tests.proj
+++ b/src/libraries/tests.proj
@@ -535,6 +535,10 @@
     <GrpcTestProject Include="$(RepoRoot)\src\tests\FunctionalTests\Android\Device_Emulator\gRPC\Android.Device_Emulator.gRPC.Test.csproj" />
   </ItemGroup>
 
+  <ItemGroup Condition="'$(RunSmokeTestsOnly)' == 'true' and '$(Scenario)' == 'WasmTestOnNodeJS'">
+    <SmokeTestProject Include="$(MSBuildThisFileDirectory)System.Net.Http\tests\FunctionalTests\System.Net.Http.Functional.Tests.csproj" />
+    <SmokeTestProject Include="$(MSBuildThisFileDirectory)System.Net.WebSockets.Client\tests\System.Net.WebSockets.Client.Tests.csproj" />
+  </ItemGroup>
   <ItemGroup Condition="'$(TargetOS)' == 'wasi'">
     <SmokeTestProject Include="$(MSBuildThisFileDirectory)Microsoft.XmlSerializer.Generator\tests\Microsoft.XmlSerializer.Generator.Tests.csproj" />
     <SmokeTestProject Include="$(MSBuildThisFileDirectory)System.AppContext\tests\System.AppContext.Tests.csproj" />