diff --git a/src/tests/issues.targets b/src/tests/issues.targets
index 5ea0e184af010d..adea69250d10c0 100644
--- a/src/tests/issues.targets
+++ b/src/tests/issues.targets
@@ -874,6 +874,9 @@
         <ExcludeList Include="$(XunitTestBinBase)/JIT/opt/ObjectStackAllocation/ObjectStackAllocationTests/*">
             <Issue>https://github.com/dotnet/runtime/issues/81103</Issue>
         </ExcludeList>
+        <ExcludeList Include = "$(XunitTestBinBase)/Loader/classloader/Casting/Functionpointer/**">
+            <Issue>https://github.com/dotnet/runtime/issues/81106</Issue>
+        </ExcludeList>
     </ItemGroup>
 
     <!-- Crossgen2 x86 specific excludes -->