diff --git a/eng/pipelines/runtime.yml b/eng/pipelines/runtime.yml
index 167838aab80c33..c7bdb13bbbe1e7 100644
--- a/eng/pipelines/runtime.yml
+++ b/eng/pipelines/runtime.yml
@@ -1138,6 +1138,7 @@ extends:
           runtimeFlavor: mono
           platforms:
             - osx_x64
+            - linux_arm64
           variables:
             - name: timeoutPerTestInMinutes
               value: 60
diff --git a/src/tests/issues.targets b/src/tests/issues.targets
index d0e374bf4992de..01ac97995ad994 100644
--- a/src/tests/issues.targets
+++ b/src/tests/issues.targets
@@ -3271,6 +3271,90 @@
         </ExcludeList>
     </ItemGroup>
 
+    <ItemGroup Condition="'$(RuntimeFlavor)' == 'mono' and '$(RuntimeVariant)' == 'minijit' and '$(TargetArchitecture)' == 'arm64'">
+        <ExcludeList Include="$(XunitTestBinBase)/Interop/SuppressGCTransition/SuppressGCTransitionTest/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/Interop/NativeLibrary/API/NativeLibraryTests/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/Interop/NativeLibrary/Callback/CallbackStressTest_TargetUnix/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/Interop/NativeLibrary/Callback/CallbackTests/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/Interop/UnmanagedCallConv/UnmanagedCallConvTest/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/Interop/ICustomMarshaler/ConflictingNames/SameNameDifferentAssembly/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/Interop/UnmanagedCallersOnlyBasic/UnmanagedCallersOnlyBasicTest/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/Interop/PInvoke/Primitives/Pointer/NonBlittablePointer/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/Interop/PInvoke/SetLastError/SetLastErrorTest/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/Interop/PInvoke/Primitives/Int/PInvokeIntTest/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/Interop/PInvoke/Miscellaneous/HandleRef/HandleRefTest/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/Interop/PInvoke/Miscellaneous/MultipleAssembliesWithSamePInvoke/MAWSPITest/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/Interop/PInvoke/Vector2_3_4/Vector2_3_4/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/Interop/PInvoke/Primitives/RuntimeHandles/RuntimeHandlesTest/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/Interop/MonoAPI/MonoMono/InstallEHCallback/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/Interop/MonoAPI/MonoMono/Thunks/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/Interop/MonoAPI/MonoMono/PInvokeDetach/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/Interop/StructMarshalling/ReversePInvoke/MarshalSeqStruct/DelegatePInvoke/DelegatePInvokeTest/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/JIT/Directed/pinvoke/tail/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/JIT/Directed/aliasing_retbuf/aliasing_retbuf/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/JIT/Directed/callconv/PlatformDefaultMemberFunction/PlatformDefaultMemberFunctionTest/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/JIT/Directed/callconv/StdCallMemberFunction/StdCallMemberFunctionTest/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/JIT/Directed/callconv/ThisCall/ThisCallTest/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/JIT/Directed/callconv/CdeclMemberFunction/CdeclMemberFunctionTest/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+        <ExcludeList Include = "$(XunitTestBinBase)/JIT/Methodical/gc_poll/InsertGCPoll/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/JIT/Regression/JitBlue/Runtime_76194/Runtime_76194/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/Exceptions/ForeignThread/ForeignThreadExceptions/**">
+            <Issue>https://github.com/dotnet/runtime/issues/82859</Issue>
+        </ExcludeList>
+    </ItemGroup>
+
     <ItemGroup Condition=" '$(RuntimeFlavor)' == 'mono' and '$(TargetArchitecture)' == 'arm64' and '$(TargetsWindows)' != 'true' " >
         <ExcludeList Include="$(XunitTestBinBase)/baseservices/typeequivalence/simple/Simple/**">
             <Issue>Doesn't compile with LLVM AOT.</Issue>