diff --git a/lib/response.js b/lib/response.js
index 7a2f0ecce56..a98806fbaee 100644
--- a/lib/response.js
+++ b/lib/response.js
@@ -62,6 +62,10 @@ module.exports = res
  */
 
 res.status = function status(code) {
+  // Prevent BigInt serialization error
+  if (typeof code !== 'number') {
+    throw new TypeError(`Invalid status code: ${code} (${typeof code}). Status code must be a number.`);
+  }
   // Check if the status code is not an integer
   if (!Number.isInteger(code)) {
     throw new TypeError(`Invalid status code: ${JSON.stringify(code)}. Status code must be an integer.`);
diff --git a/test/res.status.js b/test/res.status.js
index 59c8a57e702..181f2df976a 100644
--- a/test/res.status.js
+++ b/test/res.status.js
@@ -200,6 +200,18 @@ describe('res', function () {
           .get('/')
           .expect(500, /Invalid status code/, done);
       });
+
+      it('should raise error for BigInt status code', function (done) {
+        var app = express()
+
+        app.use(function (req, res) {
+          res.status(200n).end()
+        })
+
+        request(app)
+          .get('/')
+          .expect(500, /Invalid status code/, done)
+      })
     });
   });
 });