diff --git a/CHANGELOG.md b/CHANGELOG.md
index 71c8e6f225..2cc59b8f81 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -4,6 +4,7 @@
 
 ### Fixes
 
+- Fail when building Blazor WASM with Profiling. We don't support profiling in Blazor WebAssembly projects. ([#4512](https://github.com/getsentry/sentry-dotnet/pull/4512))
 - Do not overwrite user IP if it is set manually in ASP.NET sdk ([#4513](https://github.com/getsentry/sentry-dotnet/pull/4513))
 
 ## 5.15.0
diff --git a/src/Sentry.Profiling/buildTransitive/Sentry.Profiling.targets b/src/Sentry.Profiling/buildTransitive/Sentry.Profiling.targets
index 77d521f2c9..a878b98699 100644
--- a/src/Sentry.Profiling/buildTransitive/Sentry.Profiling.targets
+++ b/src/Sentry.Profiling/buildTransitive/Sentry.Profiling.targets
@@ -8,5 +8,7 @@
            Condition="'$(TargetPlatformIdentifier)' == 'android'" />
     <Error Text="Package Sentry.Profiling is not supported on platform '$(TargetPlatformIdentifier)'. The profiler is already part of the main Sentry package."
            Condition="'$(TargetPlatformIdentifier)' == 'ios' or '$(TargetPlatformIdentifier)' == 'maccatalyst'" />
+    <Error Text="Package Sentry.Profiling is not supported with Blazor WebAssembly. Please remove Sentry.Profiling from your project."
+           Condition="'$(UsingMicrosoftNETSdkBlazorWebAssembly)' == 'true'" />
   </Target>
 </Project>