diff --git a/experimental/packages/otlp-exporter-base/src/platform/node/http-transport-utils.ts b/experimental/packages/otlp-exporter-base/src/platform/node/http-transport-utils.ts
index 8fa7529fdc4..3392ab84c87 100644
--- a/experimental/packages/otlp-exporter-base/src/platform/node/http-transport-utils.ts
+++ b/experimental/packages/otlp-exporter-base/src/platform/node/http-transport-utils.ts
@@ -82,6 +82,9 @@ export function sendWithHttp(
   });
 
   req.setTimeout(timeoutMillis, () => {
+    if (req.destroyed) {
+      return;
+    }
     req.destroy();
     onDone({
       status: 'failure',