fix go-time-65 unintelligible 00:06:06.25

Author: tom-harvey

gotime/go-time-65.md

@@ -52,7 +52,7 @@ So what Mendelics does is we receive patients here who are sent to us by a physi
 
 **Carlisia Pinto:** I came prepared, that's all.
 
-**Vitor De Mario:** Yeah, so there are two pieces to this, two about the data. Usually, we have very little data. What comes out of our lab and comes out of the bioinformatics software is just a list of mutations. It says "Oh, for this person, she has a mutation on the chromosome tree, this specific mutation. She should have a \[unintelligible 00:06:06.25\]" That's it. And we have a whole list for each person, saying every mutation that they have. But those don't mean much, because in this list of mutations there is the color of your hair, the color of your eyes - all the kind of things that make you who you are, make you special. And in the middle of all of it there's also things that cause diseases, so what we wanna do is we wanna separate these mutations from the ones that don't cause any problem.
+**Vitor De Mario:** Yeah, so there are two pieces to this, two about the data. Usually, we have very little data. What comes out of our lab and comes out of the bioinformatics software is just a list of mutations. It says "Oh, for this person, she has a mutation on the chromosome tree, this specific mutation. She should have an [A](https://en.wikipedia.org/wiki/Adenine) here; she has a [G](https://en.wikipedia.org/wiki/Guanine). That's it. And we have a whole list for each person, saying every mutation that they have. But those don't mean much, because in this list of mutations there is the color of your hair, the color of your eyes - all the kind of things that make you who you are, make you special. And in the middle of all of it there's also things that cause diseases, so what we wanna do is we wanna separate these mutations from the ones that don't cause any problem.
 
 The way we do it is the first part, without any machine learning, is just we have a lot of databases from bioinformatics tools; most of those we didn't build them, they are things that can be used by anyone working with bioinformatics. That tells us more information about each mutation, or about each position in the genome. They say, "Oh, this position is very conserved", so pretty much all of the species we know that we have the sequence of their DNA, they have the same position, and we never see any different. So this becomes a number, which was created by a specific research project, and then this number is used by our software later to say if this is very relevant, to say if a mutation causes diseases or not.