diff --git a/TUnit.Assertions.Tests/CollectionStructuralEquivalenceTests.cs b/TUnit.Assertions.Tests/CollectionStructuralEquivalenceTests.cs
index 7660b6fa19..bcbf7a94ec 100644
--- a/TUnit.Assertions.Tests/CollectionStructuralEquivalenceTests.cs
+++ b/TUnit.Assertions.Tests/CollectionStructuralEquivalenceTests.cs
@@ -186,6 +186,59 @@ public async Task Collections_With_Custom_Comparer_Uses_Custom_Comparer()
 
         await TUnitAssert.That(listA).IsEquivalentTo(listB).Using(StringComparer.OrdinalIgnoreCase);
     }
+
+    /// <summary>
+    /// Tests for issue #3722: IsEquivalentTo does not respect IEquatable{T} for types like Vector2
+    /// </summary>
+    [Test]
+    public async Task Collections_With_Vector2_Are_Equivalent_Using_IEquatable()
+    {
+        var array = new System.Numerics.Vector2[]
+        {
+            new System.Numerics.Vector2(1, 2),
+            new System.Numerics.Vector2(3, 4),
+            new System.Numerics.Vector2(5, 6),
+        };
+        var list = new List<System.Numerics.Vector2>(array);
+
+        await TUnitAssert.That(array).IsEquivalentTo(list);
+    }
+
+    [Test]
+    public async Task Collections_With_Vector2_Different_Values_Are_Not_Equivalent()
+    {
+        var array = new System.Numerics.Vector2[]
+        {
+            new System.Numerics.Vector2(1, 2),
+            new System.Numerics.Vector2(3, 4),
+        };
+        var list = new List<System.Numerics.Vector2>
+        {
+            new System.Numerics.Vector2(1, 2),
+            new System.Numerics.Vector2(5, 6),
+        };
+
+        await TUnitAssert.That(array).IsNotEquivalentTo(list);
+    }
+
+    [Test]
+    public async Task Collections_With_Uri_Are_Equivalent_Using_IEquatable()
+    {
+        var listA = new List<Uri> { new Uri("http://example.com"), new Uri("http://test.com") };
+        var listB = new List<Uri> { new Uri("http://example.com"), new Uri("http://test.com") };
+
+        await TUnitAssert.That(listA).IsEquivalentTo(listB);
+    }
+
+    [Test]
+    public async Task Collections_With_Uri_Different_Values_Are_Not_Equivalent()
+    {
+        var listA = new List<Uri> { new Uri("http://example.com") };
+        var listB = new List<Uri> { new Uri("http://different.com") };
+
+        await TUnitAssert.That(listA).IsNotEquivalentTo(listB);
+    }
+
     public class Message
     {
         public string? Content { get; set; }
diff --git a/TUnit.Assertions/Conditions/Helpers/ReflectionHelper.cs b/TUnit.Assertions/Conditions/Helpers/ReflectionHelper.cs
index c6c53162c5..ab52490c39 100644
--- a/TUnit.Assertions/Conditions/Helpers/ReflectionHelper.cs
+++ b/TUnit.Assertions/Conditions/Helpers/ReflectionHelper.cs
@@ -11,6 +11,7 @@ internal static class ReflectionHelper
 {
     /// <summary>
     /// Gets all public instance properties and fields to compare for structural equivalency.
+    /// Filters out indexed properties (like indexers) that require parameters.
     /// </summary>
     /// <param name="type">The type to get members from.</param>
     /// <returns>A list of PropertyInfo and FieldInfo members.</returns>
@@ -19,7 +20,17 @@ public static List<MemberInfo> GetMembersToCompare(
         Type type)
     {
         var members = new List<MemberInfo>();
-        members.AddRange(type.GetProperties(BindingFlags.Public | BindingFlags.Instance));
+        
+        // Filter out indexed properties (properties with parameters like this[int index])
+        var properties = type.GetProperties(BindingFlags.Public | BindingFlags.Instance);
+        foreach (var prop in properties)
+        {
+            if (prop.GetIndexParameters().Length == 0)
+            {
+                members.Add(prop);
+            }
+        }
+        
         members.AddRange(type.GetFields(BindingFlags.Public | BindingFlags.Instance));
         return members;
     }
diff --git a/TUnit.Assertions/Conditions/Helpers/TypeHelper.cs b/TUnit.Assertions/Conditions/Helpers/TypeHelper.cs
index 856a05d9e6..7715a11946 100644
--- a/TUnit.Assertions/Conditions/Helpers/TypeHelper.cs
+++ b/TUnit.Assertions/Conditions/Helpers/TypeHelper.cs
@@ -1,4 +1,5 @@
 using System.Collections.Concurrent;
+using System.Diagnostics.CodeAnalysis;
 
 namespace TUnit.Assertions.Conditions.Helpers;
 
@@ -59,6 +60,8 @@ public static void ClearCustomPrimitives()
     /// </summary>
     /// <param name="type">The type to check.</param>
     /// <returns>True if the type should use value equality; false for structural comparison.</returns>
+    [UnconditionalSuppressMessage("Trimming", "IL2067",
+        Justification = "This method is only called from code paths that already require reflection (StructuralEqualityComparer)")]
     public static bool IsPrimitiveOrWellKnownType(Type type)
     {
         // Check user-defined primitives first (fast path for common case)
@@ -67,18 +70,55 @@ public static bool IsPrimitiveOrWellKnownType(Type type)
             return true;
         }
 
-        return type.IsPrimitive
-               || type.IsEnum
-               || type == typeof(string)
-               || type == typeof(decimal)
-               || type == typeof(DateTime)
-               || type == typeof(DateTimeOffset)
-               || type == typeof(TimeSpan)
-               || type == typeof(Guid)
+        if (type.IsPrimitive
+            || type.IsEnum
+            || type == typeof(string)
+            || type == typeof(decimal)
+            || type == typeof(DateTime)
+            || type == typeof(DateTimeOffset)
+            || type == typeof(TimeSpan)
+            || type == typeof(Guid)
 #if NET6_0_OR_GREATER
-               || type == typeof(DateOnly)
-               || type == typeof(TimeOnly)
+            || type == typeof(DateOnly)
+            || type == typeof(TimeOnly)
 #endif
-            ;
+           )
+        {
+            return true;
+        }
+
+        // Check if the type is a value type (struct) that implements IEquatable<T> for itself
+        // Value types like Vector2, Matrix3x2, etc. that implement IEquatable<T>
+        // should use value equality rather than structural comparison.
+        // We only check value types to avoid affecting records/classes that may have
+        // collection properties requiring structural comparison.
+        if (type.IsValueType && ImplementsSelfEquatable(type))
+        {
+            return true;
+        }
+
+        return false;
+    }
+
+    /// <summary>
+    /// Checks if a type implements IEquatable{T} where T is the type itself.
+    /// </summary>
+    private static bool ImplementsSelfEquatable(
+        [DynamicallyAccessedMembers(DynamicallyAccessedMemberTypes.Interfaces)]
+        Type type)
+    {
+        // Iterate through interfaces to find IEquatable<T> where T is the type itself
+        // This approach is AOT-compatible as it doesn't use MakeGenericType
+        foreach (var iface in type.GetInterfaces())
+        {
+            if (iface.IsGenericType 
+                && iface.GetGenericTypeDefinition() == typeof(IEquatable<>)
+                && iface.GenericTypeArguments[0] == type)
+            {
+                return true;
+            }
+        }
+        
+        return false;
     }
 }