diff --git a/.changeset/curly-snakes-whisper.md b/.changeset/curly-snakes-whisper.md
new file mode 100644
index 00000000..9ced3bae
--- /dev/null
+++ b/.changeset/curly-snakes-whisper.md
@@ -0,0 +1,5 @@
+---
+"@tsplus/runtime": patch
+---
+
+Add UUID Brand
diff --git a/packages/runtime/_src/Brand.ts b/packages/runtime/_src/Brand.ts
index 3df963aa..14a941d5 100644
--- a/packages/runtime/_src/Brand.ts
+++ b/packages/runtime/_src/Brand.ts
@@ -123,8 +123,7 @@ export type Regex<R extends string> = Brand.Validated<string, `Regex(${R})`>
 export function deriveRegexValidation<B extends string, V extends `Regex(${string})`>(
   ...[regexStr]: V extends `Regex(${infer R extends string})` ? [R] : never
 ): Brand.Validation<B, V> {
-  const r = new RegExp(regexStr)
-  return validation((b) => r.test(b))
+  return validation((b) => new RegExp(regexStr).test(b))
 }
 
 export type Min<N extends number> = Brand.Validated<number, `Min(${N})`>
@@ -207,3 +206,9 @@ export type Int = Brand.ValidatedWith<typeof Int>
 /** @tsplus implicit */
 export const Finite = Brand.validation<number, "Finite">((n: number) => Number.isFinite(n))
 export type Finite = Brand.ValidatedWith<typeof Finite>
+
+/** @tsplus implicit */
+export const UUID = Brand.validation<string, "UUID">((s) =>
+  /^[0-9a-fA-F]{8}\b-[0-9a-fA-F]{4}\b-[0-9a-fA-F]{4}\b-[0-9a-fA-F]{4}\b-[0-9a-fA-F]{12}$/gi.test(s)
+)
+export type UUID = Brand.ValidatedWith<typeof UUID>
diff --git a/packages/runtime/_src/global.ts b/packages/runtime/_src/global.ts
index 1ef5d82c..f98d660d 100644
--- a/packages/runtime/_src/global.ts
+++ b/packages/runtime/_src/global.ts
@@ -3,7 +3,7 @@ import "@tsplus/stdlib/global"
 /**
  * @tsplus global
  */
-import { Brand, Finite, Int, Max, Min, Positive, Range, Regex } from "@tsplus/runtime/Brand"
+import { Brand, Finite, Int, Max, Min, Positive, Range, Regex, UUID } from "@tsplus/runtime/Brand"
 /**
  * @tsplus global
  */
diff --git a/packages/runtime/_test/Guard.test.ts b/packages/runtime/_test/Guard.test.ts
index 1a25bfdc..fa433b9b 100644
--- a/packages/runtime/_test/Guard.test.ts
+++ b/packages/runtime/_test/Guard.test.ts
@@ -1,3 +1,5 @@
+import crypto from "node:crypto"
+
 describe("Guard", () => {
   it("literal", () => {
     const guardStr: Guard<"Tag"> = Derive()
@@ -241,4 +243,12 @@ describe("Guard", () => {
       console.log(x)
     })
   })
+  it("uuid", () => {
+    const guard = Derive<Guard<UUID>>()
+    assert.isFalse(guard.is("NotValud-UUID"))
+    for (let i = 0; i < 100; i++) {
+      const uuid = crypto.randomUUID()
+      assert.isTrue(guard.is(uuid))
+    }
+  })
 })