diff --git a/packages/vite/src/node/optimizer/index.ts b/packages/vite/src/node/optimizer/index.ts
index b859319c0a81e3..41b9d1a80897e0 100644
--- a/packages/vite/src/node/optimizer/index.ts
+++ b/packages/vite/src/node/optimizer/index.ts
@@ -673,6 +673,25 @@ export function runOptimizeDeps(
                 browserHash: metadata.browserHash,
               })
             }
+          } else {
+            // workaround Firefox warning by removing blank source map reference
+            // https://github.com/evanw/esbuild/issues/3945
+            const output = meta.outputs[o]
+            // filter by exact bytes of an empty source map
+            if (output.bytes === 93) {
+              const jsMapPath = path.resolve(o)
+              const jsPath = jsMapPath.slice(0, -4)
+              if (fs.existsSync(jsPath) && fs.existsSync(jsMapPath)) {
+                const map = JSON.parse(fs.readFileSync(jsMapPath, 'utf-8'))
+                if (map.sources.length === 0) {
+                  const js = fs.readFileSync(jsPath, 'utf-8')
+                  fs.writeFileSync(
+                    jsPath,
+                    js.slice(0, js.lastIndexOf('//# sourceMappingURL=')),
+                  )
+                }
+              }
+            }
           }
         }
 
diff --git a/playground/optimize-deps/dep-source-map-no-sources/all.js b/playground/optimize-deps/dep-source-map-no-sources/all.js
new file mode 100644
index 00000000000000..33b7c388d5f003
--- /dev/null
+++ b/playground/optimize-deps/dep-source-map-no-sources/all.js
@@ -0,0 +1,2 @@
+export const all = 'all'
+export { sub } from './sub.js'
diff --git a/playground/optimize-deps/dep-source-map-no-sources/package.json b/playground/optimize-deps/dep-source-map-no-sources/package.json
new file mode 100644
index 00000000000000..cd0db894af0ceb
--- /dev/null
+++ b/playground/optimize-deps/dep-source-map-no-sources/package.json
@@ -0,0 +1,9 @@
+{
+  "name": "@vitejs/test-dep-source-map-no-sources",
+  "private": true,
+  "version": "0.0.0",
+  "type": "module",
+  "exports": {
+    "./*": "./*"
+  }
+}
diff --git a/playground/optimize-deps/dep-source-map-no-sources/sub.js b/playground/optimize-deps/dep-source-map-no-sources/sub.js
new file mode 100644
index 00000000000000..125abf53cf2920
--- /dev/null
+++ b/playground/optimize-deps/dep-source-map-no-sources/sub.js
@@ -0,0 +1 @@
+export const sub = 'sub'
diff --git a/playground/optimize-deps/index.html b/playground/optimize-deps/index.html
index 10ca2dc0eac439..02a869c4e5a8a7 100644
--- a/playground/optimize-deps/index.html
+++ b/playground/optimize-deps/index.html
@@ -299,3 +299,9 @@ <h2>Pre-bundle transitive dependency 'some-package.pdf'</h2>
   text('.dep-with-asset-ext-prebundled', isPreBundled)
   text('.dep-with-asset-ext-no-dual-package', original === reexport)
 </script>
+
+<script type="module">
+  // manually check Firefox doesn't show warning in devtool debugger
+  import * as sub from '@vitejs/test-dep-source-map-no-sources/sub.js'
+  import * as all from '@vitejs/test-dep-source-map-no-sources/all.js'
+</script>
diff --git a/playground/optimize-deps/package.json b/playground/optimize-deps/package.json
index a1e4c17a16f027..35383a562db30b 100644
--- a/playground/optimize-deps/package.json
+++ b/playground/optimize-deps/package.json
@@ -29,6 +29,7 @@
     "@vitejs/test-dep-optimize-exports-with-root-glob": "file:./dep-optimize-exports-with-root-glob",
     "@vitejs/test-dep-optimize-with-glob": "file:./dep-optimize-with-glob",
     "@vitejs/test-dep-relative-to-main": "file:./dep-relative-to-main",
+    "@vitejs/test-dep-source-map-no-sources": "file:./dep-source-map-no-sources",
     "@vitejs/test-dep-with-asset-ext1.pdf": "file:./dep-with-asset-ext/dep1",
     "@vitejs/test-dep-with-asset-ext2.pdf": "file:./dep-with-asset-ext/dep2",
     "@vitejs/test-dep-with-builtin-module-cjs": "file:./dep-with-builtin-module-cjs",
diff --git a/pnpm-lock.yaml b/pnpm-lock.yaml
index 71dd2452846c51..b66c87dc9c34d0 100644
--- a/pnpm-lock.yaml
+++ b/pnpm-lock.yaml
@@ -960,6 +960,9 @@ importers:
       '@vitejs/test-dep-relative-to-main':
         specifier: file:./dep-relative-to-main
         version: file:playground/optimize-deps/dep-relative-to-main
+      '@vitejs/test-dep-source-map-no-sources':
+        specifier: file:./dep-source-map-no-sources
+        version: file:playground/optimize-deps/dep-source-map-no-sources
       '@vitejs/test-dep-with-asset-ext1.pdf':
         specifier: file:./dep-with-asset-ext/dep1
         version: file:playground/optimize-deps/dep-with-asset-ext/dep1
@@ -1085,6 +1088,8 @@ importers:
 
   playground/optimize-deps/dep-relative-to-main: {}
 
+  playground/optimize-deps/dep-source-map-no-sources: {}
+
   playground/optimize-deps/dep-with-asset-ext/dep1: {}
 
   playground/optimize-deps/dep-with-asset-ext/dep2:
@@ -3293,6 +3298,9 @@ packages:
   '@vitejs/test-dep-self-reference-url-worker@file:playground/worker/dep-self-reference-url-worker':
     resolution: {directory: playground/worker/dep-self-reference-url-worker, type: directory}
 
+  '@vitejs/test-dep-source-map-no-sources@file:playground/optimize-deps/dep-source-map-no-sources':
+    resolution: {directory: playground/optimize-deps/dep-source-map-no-sources, type: directory}
+
   '@vitejs/test-dep-that-imports@file:playground/external/dep-that-imports':
     resolution: {directory: playground/external/dep-that-imports, type: directory}
 
@@ -8851,6 +8859,8 @@ snapshots:
 
   '@vitejs/test-dep-self-reference-url-worker@file:playground/worker/dep-self-reference-url-worker': {}
 
+  '@vitejs/test-dep-source-map-no-sources@file:playground/optimize-deps/dep-source-map-no-sources': {}
+
   '@vitejs/test-dep-that-imports@file:playground/external/dep-that-imports(typescript@5.6.3)':
     dependencies:
       slash3: slash@3.0.0