Changes in GROMACS 2025.4 cause warning and simulation failure when following Lipid bilayers - Part I tutorial

[digispiders]

Hello all,

When following the Lipid bilayers - Part I tutorial, and attempting to perform the self-assembly MD simulation using the supplied martini_md.mdp run settings file (from the bilayer-lipidome-tutorial-I_minimal.tgz) in GROMACS 2025.4, a warning is triggered and the simulation fails. This appears to be related to changes introduced in GROMACS 2025.4 related to issues #5424 and 5425.

Steps to reproduce:
Fresh install of GROMACS 2025.4
Follow tutorial up to self-assembly MD simulation portion
Execute "gmx grompp -f martini_md.mdp -c minimized.gro -p dspc.top -o dspc-md.tpr"

Result:

...
Ignoring obsolete mdp entry 'ns_type'

NOTE 1 [file martini_md.mdp]:
  verlet-buffer-pressure-tolerance is ignored when verlet-buffer-tolerance
  < 0


WARNING 1 [file martini_md.mdp]:
  For proper integration of the C-rescale barostat, tau-p (4) should be at
  least 25 times larger than nstpcouple*dt (0.4)
...
Fatal error:
Too many warnings (1).
If you are sure all warnings are harmless, use the -maxwarn option.

Run terminates

What should happen:
Run completes without warnings, or the user is directed to modify the martini_md.mdp to avoid the warning (or some other form of flagging the issue and instructing the user how to work around the problem).

I hope this is helpful,
Ron